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TARGETMOL CHEMICALS INC EM 163 5MG
Supplier: TARGETMOL CHEMICALS INC T411425MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. EM 163 is a TIR-TIR interaction inhibitor which is a TIR (Toll/interleukin-1 receptor) structural domain mimic of the MyD88 protein. EM 163 targets the TIR structural domain in the IL-1 receptor and blocks the interaction with MyD88. EM 163 inhibits the production of inflammatory cytokines in vivo caused by staphylococcal enterotoxin B (SEB). EM 163 protects mice from SEB shock-induced death. In rat hippocampal neurons in vitro EM 163 blocked the activation of p38 and the inhibitory effect of IL-1(beta) on chemically induced long-term potentiation (LTP)-triggered protein synthesis. purity: 99%
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