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Medchemexpress LLC EMD638683 | 1181770-72-8 | C18H18F2N2O4 | 1 ML
Supplier: Medchemexpress LLC HY1519310MM/1ML
EMD638683 is an orally active SGK1 inhibitor with an IC50 of 3 μM. It demonstrates strong inhibition against SGK1, moderate inhibition against SGK2 and SGK3, and excellent selectivity for other AGC kinase family members. This compound exhibits antihypertensive activity by inhibiting SGK1, and prevents heart inflammation and fibrosis caused by hypertension by inhibiting the cardiac NLRP3 inflammation body/IL-1β axis, independent of its blood pressure-lowering effect.
- Orally active SGK1 inhibitor
- Strongly inhibits SGK1, moderately inhibits SGK2 and SGK3
- Shows excellent selectivity for other AGC kinase family members
- Exhibits antihypertensive activity
- Prevents heart inflammation and fibrosis caused by hypertension
- Promotes apoptosis in colon cancer cells
- Sensitizes colon cancer cells to radiotherapy
- Suitable for research related to hypertension, hypertensive heart damage, and colon cancer
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