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Medchemexpress LLC EMD638683 | 1181770-72-8 | C18H18F2N2O4 | 5 MG
Supplier: Medchemexpress LLC HY151935MG
EMD638683 is an orally active SGK1 inhibitor with an IC50 of 3 μM, demonstrating strong inhibition of SGK1 and moderate inhibition of SGK2 and SGK3. This compound exhibits excellent selectivity for other AGC kinase family members. It possesses antihypertensive activity by inhibiting SGK1 and effectively prevents heart inflammation and fibrosis caused by hypertension by inhibiting the cardiac NLRP3 inflammation body/IL-1β axis. EMD638683 also promotes apoptosis of colon cancer cells and sensitizes radiotherapy, making it suitable for research concerning hypertension, hypertensive heart damage, and colon cancer.
- Strongly inhibits SGK1 with high selectivity
- Exhibits antihypertensive activity
- Prevents heart inflammation and fibrosis
- Promotes apoptosis in colon cancer cells
- Sensitizes radiotherapy for colon cancer
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