Medchemexpress LLC En450 Nf-κb degrader | 793719-01-4 | 98.6% | C11H13ClN2O3S | 5 MG

Supplier:  Medchemexpress LLC HY494445MG

EN450 is a cysteine-reactive covalent molecular glue degrader that targets NF-κB. It interacts with the allosteric C111 in the E2 ubiquitin ligase UBE2D and induces the formation of a ternary complex between UBE2D and NFKB1. This compound achieves its anti-proliferative effects through a Cullin E3 ligase and proteasome-dependent mechanism, significantly inhibiting the proliferation of HAP1 leukemia cancer cells and HEK293T cells, and reducing the levels of the p105 and p50 subunits of NFκB1.

• Targets Nf-κb
• Interacts with allosteric C111 in the E2 ubiquitin ligase UBE2D
• Induces ternary complex formation between UBE2D and NFKB1
• Achieves anti-proliferative effects via Cullin E3 ligase and proteasome-dependent mechanism
• Inhibits proliferation of HAP1 leukemia cancer cells and HEK293T cells
• Reduces levels of p105 and p50 subunits of NFκB1

Catalog No. 50-003-57794