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Medchemexpress LLC Encaleret | 787583-71-5 | 99.88% | C29H33ClFNO4 | 25 MG
Supplier: Medchemexpress LLC 25MGHY14401
Encaleret (CLTX-305) is an orally active antagonist of the calcium-sensing receptor (CaSR) with an IC50 of 12 nM. It functions by inhibiting the excessive activity of functional gain-of-function CaSR variants. This action helps to restore blood calcium levels, promote the secretion of parathyroid hormone, improve magnesium and phosphorus metabolism, and increase urinary calcium excretion. Encaleret is intended for research purposes, particularly in studies related to diseases such as osteoporosis and autosomal dominant hypocalcemia type 1.
- Orally active
- Potent CaSR antagonist (IC50 of 12 nM)
- Restores blood calcium levels
- Promotes parathyroid hormone secretion
- Improves magnesium and phosphorus metabolism
- Increases urinary calcium excretion
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