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Medchemexpress LLC Endoxifen (hydrochloride) | 1197194-41-4 | 98.0% | 409.95 | 100 MG
Supplier: Medchemexpress LLC HY18719B100MG
Endoxifen hydrochloride is a key active metabolite of Tamoxifen with higher affinity and specificity to estrogen receptor that also inhibits aromatase activity. It has potential for breast cancer study.
- More potent ER antagonist than tamoxifen.
- Induces ER-alpha degradation and inhibits ER transcriptional activity.
- Targets estrogen receptor α for degradation in breast cancer cells, inhibiting proliferation.
- Exhibits strong growth inhibitory and cytotoxic effects on breast cancer cell lines at 10 μM.
- Rapidly absorbed and systemically available; leads to higher exposure levels than tamoxifen.
- Safe and effective in inhibiting human mammary tumor xenografts in female mice orally.
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