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Medchemexpress LLC Endoxifen Z-isomer hydrochloride | 1032008-74-4 | 99.67% | 409.95 | 5 MG
Supplier: Medchemexpress LLC HY187195MG
Endoxifen Z-isomer hydrochloride is an orally active Tamoxifen metabolite that acts as a selective estrogen receptor modulator. It is significantly more potent than Tamoxifen, with 100-fold greater efficacy. This compound inhibits PKCβ1 kinase activity and demonstrates anticancer properties against hormone-resistant metastatic breast cancer.
- Inhibits PKCβ1 kinase activity
- Reduces AKTSer473 phosphorylation
- Diminishes AKT substrate phosphorylation
- Induces apoptosis
- Potent antiproliferative activity against MCF7AC1 and MCF7LR cell lines
- Shows better antitumor efficacy in MCF7LR resistant mouse model
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