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Apexbio Technology LLC Enzastaurin (LY317615) 170364-57-5 100mg
Supplier: Apexbio Technology LLC A1670100
Enzastaurin (LY317615 CAS 170364-57-5) is an orally bioavailable ATP-competitive inhibitor selective for protein kinase C beta (PKC ) a member of the serine-threonine kinase family implicated in tumor growth and progression By inhibiting PKC (IC50 6 nM) enzastaurin decreases phosphorylation and signaling of downstream effectors including ribosomal protein S6 GSK3 and AKT In cellular assays enzastaurin reduces proliferation and induces apoptosis across diverse tumor types (e g colon cancer HCT-116 glioblastoma U87MG) In vivo studies demonstrate antitumor efficacy in xenograft models highlighting its utility for oncology research
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