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Medchemexpress LLC Enzastaurin (LY317615) | 170364-57-5 | 99.8% | 515.61 | 10 MG
SDP

Supplier:  Medchemexpress LLC 10MGHY10342

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Enzastaurin (LY317615) is a potent, selective, and CNS-penetrant PKCβ inhibitor with an IC50 of 6 nM, showing 6- to 20-fold selectivity over PKCα, PKCγ and PKCε.

  • Potent, selective, and CNS-penetrant PKCβ inhibitor
  • Induces apoptosis and suppresses proliferation in cultured tumor cells
  • Suppresses the phosphorylation of GSK3βser9, ribosomal protein S6S240/244, and AKTThr308
  • Increases apoptosis in malignant lymphocytes of CTCL
  • When combined with GSK3 inhibitors, enhances cytotoxicity levels
  • Treatment with Enzastaurin and radiation produces greater reductions in density of microvessels and delays tumor growth in xenografts

Catalog No. 50-003-64963


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