Apexbio Technology LLC Epirubicin HCl 56390-09-1 10mM (in 1mL DMSO)

Supplier:  Apexbio Technology LLC A24515.1

Epirubicin HCl is an anthracycline antibiotic with antitumor activity targeting DNA topoisomerase II (TOPII) It functions by stabilizing TOPII-DNA cleavable complexes resulting in increased DNA double-strand breaks subsequent activation of DNA damage responses and initiation of apoptosis pathways Consequently epirubicin is frequently utilized in anticancer research particularly against osteosarcoma cells Studies demonstrate epirubicin induces apoptosis in osteosarcoma models yet it can also activate resistance pathways such as NF- B affecting therapeutic efficacy The reported IC50 values of epirubicin in osteosarcoma cell lines typically range between approximately 0 1 to 2 M based on experimental conditions This compound is thus actively employed in oncology research exploring DNA-damaging agents or combination therapy strategies in cell-based assays and animal models

Catalog No. 50-000-62973