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Apexbio Technology LLC Eplerenone 107724-20-9 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC A84245.1
Eplerenone (107724-20-9) is a small-molecule antagonist targeting the mineralocorticoid receptor (MR) It is designed to competitively block aldosterone binding to MR thereby modulating aldosterone-mediated signaling pathways Eplerenone exerts its biological activity primarily through selective mineralocorticoid receptor antagonism In in vitro studies Eplerenone demonstrates inhibition of MR activation with an IC50 value of approximately 0 081 M Based on these pharmacological properties Eplerenone holds research potential in cardiovascular studies including the investigation of aldosterone-associated mechanisms in hypertension atherosclerosis cardiac remodeling vascular impairment and chronic systolic heart failure
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