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Medchemexpress LLC EPZ004777 hydrochloride | 1380316-03-9 | C28H42ClN7O4 | 50 MG
Supplier: Medchemexpress LLC HY15227A50MG
EPZ004777 hydrochloride is an effective and selective DOT1L inhibitor, reducing H3K79me2 and H3K79me1 levels and down-regulating HOXA9 and MEIS1 expression. This compound selectively inhibits the proliferation of MLL rearrangement cells, promoting their differentiation and apoptosis, making it useful for leukemia research.
- Target: histone methyltransferase; apoptosis
- Pathway: epigenetics; apoptosis
- Potent and selective DOT1L inhibitor (IC50 of 0.4 nM)
- Reduces H3K79me2 and H3K79me1 levels, down-regulating HOXA9 and MEIS1 expression
- Selectively inhibits MLL rearrangement cells, promoting differentiation and apoptosis
- Well tolerated in vivo with no overt toxicity observed
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