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Cayman Chemical Erastin, 571203-78-6, 1 mg
Supplier: Cayman Chemical 177541
Molecular Formula C30H31ClN4O4, Purity ≥98%, Formula Weight 547.1; A ferroptosis inducer; induces ferroptotic cell death in vitro, an effect that can be blocked by ferroptosis inhibitors; inhibits cystine uptake by the system xc- cystine-glutamate transporter in HT-1080 fibrosarcoma and Calu-1 lung carcinoma cells at 5 M; inhibits glutamate release via the cystine-glutamate transporter in an enzyme-coupled fluorescence assay (EC50 = 1.2 M); selectively induces cell death in cells expressing the SV40 small T oncoprotein and oncogenic Ras (IC50s = 1.25-5 g/ml)
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