ABclonal Technology ErbB3/HER3 Rabbit pAb

Supplier:  ABclonal Technology A13976500UL

This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. It has a neuregulin binding domain but lacks an active kinase domain, so it binds the ligand without transmitting signals via protein phosphorylation. It forms heterodimers with other EGFR family members that have kinase activity, activating pathways for cell proliferation or differentiation. Amplification or overexpression of this gene is linked to various cancers, including prostate, bladder, and breast tumors. Alternative splice variants encoding different isoforms have been identified, including one isoform that lacks the intermembrane region and is secreted to modulate the membrane-bound form’s activity. Other splice variants have been reported but are not fully characterized.

Catalog No. 50-001-08486