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Cayman Chemical Ertugliflozin, 1210344-57-2, MFCD21609259, 10mg
Supplier: Cayman Chemical 2150710
Molecular Formula: C22H25ClO7, Formula Weight: 436.9, Purity ≥98%. Ertugliflozin potently inhibits the sodium-glucose cotransporter 2 (SGLT2), increasing the excretion of glucose with a 2,000-fold selectivity over SGLT1 (IC50 = 0.877 and 1,960 nM, respectively, for human isoforms in vitro). Inhibiting renal glucose reabsorption in this way offers an insulin-independent alternative to controlling blood glucose concentrations in patients with type 2 diabetes mellitus. In Phase III clinical trials at doses of 5 and 15 mg, ertugliflozin reduced plasma glucose and HbA1c levels as well as decreased body weight.
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