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Apexbio Technology LLC Etazolate hydrochloride 35838-58-5 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC B63045.1
Etazolate hydrochloride (CAS 35838-58-5) is a small molecule inhibitor of phosphodiesterase-4 (PDE-4) and a selective modulator of the GABA-A receptor PDE-4 inhibition alters the release of inflammatory mediators through cAMP-dependent and independent pathways supporting its exploration in respiratory inflammatory diseases such as asthma and chronic obstructive pulmonary disease As a GABA-A receptor modulator Etazolate hydrochloride has been shown in cortical neuron models to stimulate -secretase-mediated sAPP production and reduce amyloid- neurotoxicity Clinical studies in Alzheimer s disease patients have indicated that combination therapy with acetylcholinesterase inhibitors is safe and well-tolerated
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