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Medchemexpress LLC Ethanone, 1-[(3S)-3-amino-1-pyrrolidinyl]-2-[[(1R,2S)-2-[3,5-difluoro-2-(phenylmethoxy)phenyl] cyclopropyl]amino]-, hydrochloride (1:1) | 2262489-89-2 | 98.1% | 437.91 | 100 MG
SDP

Supplier:  Medchemexpress LLC HY136522100MG

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S2116 is an N-alkylated tranylcypromine (TCP) derivative and a potent lysine-specific demethylase 1 (LSD1) inhibitor. It increases H3K9 methylation and reciprocal H3K27 deacetylation at super-enhancer regions. This compound induces apoptosis in TCP-resistant T-cell acute lymphoblastic leukemia (T-ALL) cells by repressing the transcription of NOTCH3 and TAL1 genes, and significantly retards the growth of T-ALL cells in xenotransplanted mice.

  • Potent lysine-specific demethylase 1 (LSD1) inhibitor
  • Increases H3K9 methylation
  • Increases H3K27 deacetylation at super-enhancer regions
  • Induces apoptosis in TCP-resistant T-cell acute lymphoblastic leukemia (T-ALL) cells
  • Represses NOTCH3 and TAL1 gene transcription
  • Retards growth of T-ALL cells in xenotransplanted mice

Catalog No. 50-003-49129


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