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Apexbio Technology LLC Evans Blue tetrasodium salt 314-13-6 1g
Supplier: Apexbio Technology LLC B64721000
Evans Blue tetrasodium salt (CAS 314-13-6) is a small molecule inhibitor of non-NMDA glutamate receptors specifically targeting AMPA and kainate receptor-mediated currents It exhibits potent inhibition of GluR1 and GluR6 subunits with IC50 values of 220 nM and 150 nM respectively and suppresses GluR1 2-mediated responses at 355 nM in vitro Evans Blue does not act as a competitive antagonist at the agonist binding site but modulates receptor desensitization reducing current amplitude and modifying desensitization and recovery kinetics No in vivo or clinical studies have been reported This compound is utilized in the study of glutamatergic neurotransmission and receptor pharmacology
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