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Apexbio Technology LLC EVP-6124 hydrochloride 550999-74-1 5mg
Supplier: Apexbio Technology LLC A34075
EVP-6124 hydrochloride (CAS 550999-74-1) is the hydrochloride salt of EVP-6124 a selective partial agonist of the 7 subtype nicotinic acetylcholine receptor (nAChR) It demonstrates high affinity and specificity for 7 nAChRs in vitro and in vivo with substantially lower affinity for 4 2 nAChRs EVP-6124 is brain-penetrant with significant central exposure In preclinical models EVP-6124 increases the cortical release of dopamine acetylcholine and glutamate especially when administered with nAChR-selective antagonists It has been shown to restore memory deficits in combination with donepezil supporting its utility in investigating cognitive dysfunction and related neuropsychiatric conditions
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