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Medchemexpress LLC Ezh2-IN-14 | 1979157-17-9 | 99.0% | 541.69 | 5 MG
Supplier: Medchemexpress LLC HY1484585MG
EZH2-IN-14 is a selective EZH2 (Histone Methyltransferase) inhibitor with an IC50 of 12 nM. It inhibits the methyltransferase activity of EZH2/PRC2, thereby reducing H3K27me3. This compound demonstrates over 200-fold selectivity for EZH2 compared to the highly homologous H3K27 methyltransferase EZH1 and is for research use only.
- Selective EZH2 inhibitor with an IC50 of 12 nM
- Inhibits methyltransferase activity of EZH2/PRC2
- Reduces H3K27me3 and H3K27me2 marks in MDA-MB-468 cells
- Demonstrates high selectivity for EZH2 over EZH1
- Shows antiproliferative activity in various human cell lines
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