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Cayman Chemical Fantofarone 10mg
Supplier: Cayman Chemical 2638110 MG
A calcium channel inhibitor; inhibits the L-type voltage-gated calcium channel in isolated rat aorta (IC50 = 0.61 nM) over α1- and β-adrenergic, muscarinic, and histamine H2 receptors in rat heart homogenates (IC50s = >10, >10, 4, and >10 µM, respectively), and the serotonin receptor subtypes 5-HT1 and 5-HT2, as well as histamine H1 and adenosine A1 receptors, in rat brain homogenates (IC50s = >10, 4, >10, and >10 µM, respectively); inhibits peak calcium current in depolarized and hyperpolarized L-type voltage-gated calcium channels (IC50s = 1.4 and 150 nM, respectively); inhibits potassium chloride- and norepinephrine-induced contractions in isolated rat aorta (IC50s = 5.64 and 96 nM, respectively); enhances recovery of cardiac output during reperfusion of isolated rat hearts at 10 nM; prevents angioplasty-induced vasospasms in the femoral artery in a rabbit model of focal atherosclerosis at 50 UG/kg
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