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Medchemexpress LLC Fesoterodine fumarate | 286930-03-8 | 99.5% | C30H41NO7 | 10 MM * 1 ML
Supplier: Medchemexpress LLC HYA003010MM/1ML
Fesoterodine Fumarate is an orally active, nonsubtype selective, competitive muscarinic receptor (mAChR) antagonist. It has pKi values of 8.0, 7.7, 7.4, 7.3, and 7.5 for M1, M2, M3, M4, and M5 receptors, respectively. It is used for the treatment of overactive bladder (OAB).
- Decreases micturition frequency, urgency severity, and urgency incontinence episodes.
- Increases the volume voided with each micturition.
- Rapidly and extensively hydrolyzed in plasma to Desfesoterodine (an active metabolite of Fesoterodine) after oral administration.
- Reduces micturition pressure.
- Increases bladder capacity and intercontraction intervals (ICIs) at a dose of 0.01 mg/kg in bladders from female Sprague-Dawley rats.
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