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Apexbio Technology LLC FIIN-2 1633044-56-0 5mg
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Supplier:  Apexbio Technology LLC A86965

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FIIN-2 (CAS 1633044-56-0) is an irreversible inhibitor targeting FGFR1 4 exhibiting IC50 values of 3 1 4 3 27 and 45 nM respectively It binds covalently to the P-loop cysteine particularly Cys491 in FGFR2 and displays moderate inhibition of EGFR (IC50 204 nM) with reduced affinity compared to related compounds FIIN-2 effectively inhibits proliferation of FGFR-dependent Ba/F3 cells showing nanomolar EC50 values and demonstrates potent activity against FGFR2 gatekeeper mutations including V564M and V564F Its selective kinase profile and ability to circumvent resistance mechanisms highlight its value for studying FGFR-driven oncogenic pathways and evaluating strategies for overcoming therapeutic resistance

Catalog No. 50-224-0204


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