Apexbio Technology LLC Flavopiridol hydrochloride 131740-09-5 1g

Supplier:  Apexbio Technology LLC A86401000

Flavopiridol hydrochloride is a selective inhibitor of cyclin-dependent kinases (CDKs) specifically targeting CDK1 CDK2 CDK4 and CDK6 with reported IC50 values approximately 41 nM and CDK7 with an IC50 of about 300 nM Additionally it has been observed to inhibit EGFR and protein kinase A at micromolar concentrations By inhibiting CDK activity flavopiridol hydrochloride disrupts cell cycle progression inducing G1 phase arrest as demonstrated in breast cancer cell lines Furthermore its capacity to inhibit phosphorylation of Rb protein and suppress anti-apoptotic proteins such as Mcl-1 and XIAP facilitates apoptosis in lymphoma cell models Flavopiridol hydrochloride is utilized in preclinical studies of cell cycle regulation apoptosis signaling and cancer research including experiments using xenograft tumor models in mice

Catalog No. 50-000-61955