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Apexbio Technology LLC FLI-06 313967-18-9 25mg
Supplier: Apexbio Technology LLC B308325
FLI-06 (CAS 313967-18-9) is a small molecule inhibitor of the Notch signaling pathway exhibiting an EC50 of 2 3 M Notch signaling regulates cell fate decisions and its dysregulation is implicated in oncogenesis and developmental disorders FLI-06 impedes Notch E-eGFP accumulation and reduces NICD-eGFP production in HeLa cells with effects that are fully reversible upon washout indicating low cytotoxicity Additionally FLI-06 significantly decreases A secretion upstream of - and -secretase cleavage events and disrupts Golgi structure by interfering with early secretory pathway membrane trafficking This compound is valuable for studying Notch signaling secretory pathway dynamics and related cellular processes
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