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Medchemexpress LLC Flonoltinib TFA | 2928093-29-0 | 98.0% | 250 MG
Supplier: Medchemexpress LLC 250MGHY130247A
Flonoltinib TFA is a potent and orally active dual JAK2/FLT3 inhibitor with IC50 values of 0.7 nM, 4 nM, 26 nM and 39 nM for JAK2, FLT3, JAK1 and JAK3, respectively. It exhibits anti-cancer activity.
- Potent and orally active dual JAK2/FLT3 inhibitor
- Exhibits anti-cancer activity
- Inhibits JAK2 (0.7 nM), FLT3 (4 nM), JAK1 (26 nM), JAK3 (39 nM)
- Down-regulates p-FLT3 in a dose-dependent manner
- Induces apoptosis in MV4-11 cells
- Induces cell cycle arrest with a G1/G0 percentage of 85% at 100 nM in MV4-11 cells
- Exhibits significant antitumor effects in mouse models
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