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Medchemexpress LLC Fluticasone propionate | 80474-14-2 | 99.93% | 25 MG
Supplier: Medchemexpress LLC 25MGHYB0154
Fluticasone propionate is a potent topical anti-inflammatory corticosteroid and a selective glucocorticoid receptor agonist with an absolute affinity (KD) of 0.5 nM. It exhibits little or no activity at other steroid receptors and also shows anti-viral activity.
- Inhibits TNFα-induced E-selectin expression with an IC50 of 1 nM.
- Shows EC50 of 0.7 nM for transactivation activity at the glucocorticoid receptor in HepG2 cells.
- Exhibits ED50 of 3 μg for antiinflammatory activity in neutrophils.
- Provides IC50 of 0.1 nM for inhibition of TNFalpha release in PBMC.
- Demonstrates EC50 of 1.09 nM for agonist activity at GR in SW1353 cells.
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