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Apexbio Technology LLC Fluzoparib 1358715-18-0 10mg
Supplier: Apexbio Technology LLC A905210
Fluzoparib (1358715-18-0) is a small-molecule inhibitor targeting poly (ADP-ribose) polymerase-1 (PARP1) It is designed to inhibit PARP1 enzyme activity thereby disrupting DNA damage repair pathways Fluzoparib exerts its biological activity primarily through inhibition of PARP1-mediated DNA repair In in vitro studies Fluzoparib demonstrates potent inhibitory activity with an IC50 value of 1 46 0 72 nM It selectively suppresses the proliferation of homologous recombination (HR) deficient cells and enhances their susceptibility to cytotoxic agents Based on these pharmacological properties Fluzoparib holds research potential in oncology particularly for investigating DNA repair mechanisms and evaluating therapeutic strategies involving HR-deficient tumor models
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