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Medchemexpress LLC Forodesine | 209799-67-7 | 99.1% | 266.25 | 5 MG
Supplier: Medchemexpress LLC HY162105MG
Forodesine is a highly potent and orally active purine nucleoside phosphorylase (PNP) inhibitor with IC50 values ranging from 0.48 to 1.57 nM for human, mouse, rat, monkey, and dog PNP. It is a potent human lymphocyte proliferation inhibitor and can induce apoptosis in leukemic cells by increasing dGTP levels.
- Highly potent and orally active purine nucleoside phosphorylase (PNP) inhibitor.
- Inhibits human, mouse, rat, monkey, and dog PNP.
- Potent human lymphocyte proliferation inhibitor.
- Induces apoptosis in leukemic cells by increasing dGTP levels.
- Excellent oral bioavailability (63%) in mice.
- Elevates dGuo to approximately 5 μM at a single dose of 10 mg/kg in mice.
- Effective in prolonging the life span in the hu-PBL-SCID mouse model.
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