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Medchemexpress LLC Forodesine hydrochloride | 284490-13-7 | 98.4% | 302.71 | 25 MG
Supplier: Medchemexpress LLC 25MGHY16209
Forodesine hydrochloride is a highly potent and orally active purine nucleoside phosphorylase (PNP) inhibitor with IC50 values ranging from 0.48 to 1.57 nM for human, mouse, rat, monkey and dog PNP. It is a potent human lymphocyte proliferation inhibitor and can induce apoptosis in leukemic cells by increasing dGTP levels.
- Potent and orally active purine nucleoside phosphorylase (PNP) inhibitor.
- Inhibits human lymphocyte proliferation.
- Induces apoptosis in leukemic cells.
- Excellent oral bioavailability in mice.
- Effective in prolonging life span in mouse models.
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