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Medchemexpress LLC Fostamatinib disodium hexahydrate | 914295-16-2 | 99.5% | 1 ML
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Supplier:  Medchemexpress LLC HY1303810MM/1ML

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Fostamatinib disodium hexahydrate (R788 disodium hexahydrate) is the oral prodrug of the active compound R406. R406 is an orally available and competitive Syk/FLT3 inhibitor with a Ki of 30 nM and an IC50 of 41 nM. It also inhibits Lyn (IC50=63 nM) and Lck (IC50=37 nM).

  • Oral prodrug of R406
  • Orally available and competitive Syk/FLT3 inhibitor
  • Inhibits Lyn (IC50=63 nM)
  • Inhibits Lck (IC50=37 nM)
  • Shows cytotoxicity in Ramos cells (IC50 = 0.267 μM)
  • Highly bioavailable and rapidly absorbed
  • Inhibits phosphorylated TBK1 and IRF3 in THP-1 cells
  • Impacts proliferative capacity of PC-3 cells
  • Improves survival in mice transplanted with TEL-SYK oncogene
  • Reduces spleen and liver sizes
  • Decreases white blood cell counts

Catalog No. 50-003-39063


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