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Apexbio Technology LLC FPH1 (BRD-6125) 708219-39-0 25mg
Supplier: Apexbio Technology LLC B370125
FPH1 (BRD-6125 CAS nan) is a synthetic small-molecule compound identified to stimulate functional proliferation of primary human hepatocytes FPH1 modulates hepatocyte proliferation independent of individual donor variability promoting expansion in hepatocytes from diverse genetic backgrounds FPH1 exerts its biological activity by enhancing hepatic functions notably increasing albumin secretion during the differentiation of induced pluripotent stem (iPS) cells to hepatocyte-like cells and elevating CYP3A4 expression while suppressing alpha-fetoprotein (AFP) production In cell-based studies FPH1 demonstrates proliferative and maturation-promoting activity in primary human hepatocytes and iPS-derived hepatocyte-like cells Based on these pharmacological properties FPH1 holds research potential in hepatocyte expansion hepatic maturation and applications in biomedical and regenerative medicine research
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