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Medchemexpress LLC Frovatriptan succinate hydrate | 158930-17-7 | 99.9% | 5 MG
Supplier: Medchemexpress LLC HYB1658A5MG
Frovatriptan succinate hydrate ((R)-Frovatriptan succinate hydrate) is a potent, high-affinity, selective, and orally active agonist for 5-HT1B (pK50 of 8.2) and 5-HT1D receptors. It demonstrates over 10-fold selectivity for 5-HT1B and 5-HT1D receptors compared to 5-HT1A, 5-HT1F, and 5-HT7, and more than 1000-fold selectivity over other 5-HT, dopamine, histamine H1, and α1-adrenoceptors. This compound has potential for use in migraine research.
- Potent, high-affinity, selective 5-HT1B and 5-HT1D receptor agonist.
- Orally active.
- Exhibits >10-fold selectivity for 5-HT1B and 5-HT1D over 5-HT1A, 5-HT1F, and 5-HT7.
- Potential for migraine research.
- Oral bioavailability of 22%-30%, not affected by food. Long terminal half-life of approximately 26 hours. Metabolized primarily by CYP1A2.
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