Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
Medchemexpress LLC G-5555 hydrochloride | 2319590-15-1 | 98.3% | 529.42 | 1 ML
Supplier: Medchemexpress LLC HY19635A10MM/1ML
G-5555 hydrochloride is a potent and selective p21-activated kinase 1 (PAK1) inhibitor with a Ki of 3.7 nM.
- Excellent kinase selectivity, inhibiting only eight out of 235 kinases tested (>70% inhibition).
- High selectivity for group I PAKs.
- Negligible activity against the hERG channel (IC50 > 10 μM).
- Exhibits significantly greater growth inhibitory activity in PAK-amplified breast cancer cell lines.
- Low blood clearance and acceptable half-life in vivo.
- Good oral exposure (AUC=30 μM•h) and high oral bioavailability (F=80%) in vivo.
- Inhibits phosphorylation of MEK1 S298 and shows 60% tumor growth inhibition in xenograft models.
Product Title
By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.
Spot an opportunity for improvement?