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Apexbio Technology LLC Gabexate mesylate 56974-61-9 50mg
Supplier: Apexbio Technology LLC A401250
Gabexate mesylate (CAS 56974-61-9) is a synthetic non-antigenic inhibitor targeting serine proteases including human and bovine trypsin It competitively binds the primary specificity pocket (S1) of trypsin enzymes interacting primarily through its carbonyl group at the enzyme s oxyanion binding site Reported Ki values are 3 4 nM for human trypsin and 180 nM for bovine trypsin Gabexate mesylate also inhibits nitric oxide synthases (cNOS and iNOS Ki 150 M and 5 mM respectively) suppressing LPS/IFN -induced NO production (EC50 250 M) It is employed in research related to pancreatitis coagulation disorders and inflammation
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