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Apexbio Technology LLC Galanthamine HBr 1953-04-4 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC A17455.1
Galanthamine HBr (CAS 1953-04-4) is a long-acting centrally acting acetylcholinesterase inhibitor exhibiting an IC50 of 410 nM In addition to suppressing acetylcholinesterase activity it functions as an allosteric modulator of neuronal nicotinic acetylcholine receptors In vitro studies demonstrate that galanthamine HBr prevents -amyloid-induced apoptosis in SH-SY5Y neuroblastoma and bovine chromaffin cells Long-term exposure has been shown to attenuate the accumulation of amyloid aggregates This molecule is utilized in biomedical research related to neurodegenerative disease mechanisms cholinergic signaling and neuroprotection
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