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Apexbio Technology LLC Ganciclovir 82410-32-0 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC B20975.1
Ganciclovir (DHPG) is an antiviral compound classified as a nucleoside analog primarily utilized in research targeting cytomegalovirus (CMV) infections Its active pharmacological mechanism involves phosphorylation by viral thymidine kinase enzymes subsequently converting to ganciclovir triphosphate which inhibits viral DNA polymerase to suppress viral replication It displays inhibitory activity against herpesviruses including human cytomegalovirus herpes simplex virus types I and II and Epstein-Barr virus Research indicates ganciclovir also reduces proliferation and activation of microglia as demonstrated in experimental animal models suggesting utility for studies involving neuroinflammatory and glial cell proliferation processes Literature-reported IC50 against human CMV polymerase is approximately 0 25 M illustrating its potential use in antiviral mechanism assays and neuroscience-related inflammation research
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