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STEMCELL Technologies GANT 58, Size: 10 mg
Supplier: STEMCELL Technologies 73984
GANT 58 inhibits the Hedgehog signaling pathway downstream of Smoothened and Suppressor of Fused (SUFU) leading to GLI1 nuclear accumulation (Joo et al.; Stanton & Peng). GANT 58 demonstrates antiproliferative and antitumor activity in vivo (Beauchamp et al.; Joo et al.).CANCER RESEARCH · Reduces anchorage-independent growth in Ewing Sarcoma cells (Beauchamp et al.; Joo et al.).· Inhibits prostate cancer tumor growth (Lauth et al.).· Causes cell cycle arrest and apoptosis in acute leukemia T cells (Hou et al.).
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