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Medchemexpress LLC GANT 61 | 500579-04-4 | 99.80% | 429.60 | 25 MG
Supplier: Medchemexpress LLC 25MGHY13901
GANT 61 is a potent inhibitor of Gli1 and Gli2, effectively targeting the Hedgehog/GLI signaling pathway. This compound has demonstrated significant biological activity both in vitro and in vivo, impacting cell proliferation, viability, and tumor growth across various cancer models.
- Inhibits Gli1 and Gli2 activity
- Targets the Hedgehog/GLI pathway
- Reduces clonogenic survival in human colon carcinoma cells
- Induces apoptosis and inhibits cell viability in pancreatic cancer stem cells
- Inhibits motility, invasion, and migration of cancer stem cells
- Decreases tumor growth in xenograft models
- Enhances the effects of chemotherapeutic drugs for neuroblastoma
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