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Medchemexpress LLC GCN2-IN-7 | 2396465-33-9 | C22H23BrN8OS | 1 MG
Supplier: Medchemexpress LLC HY1514601MG
GCN2-IN-7 is an orally active and selective general control nonderepressible 2 (GCN2) inhibitor with an IC50 of 5 nM. It demonstrates anti-tumor activity in vivo and is intended for research use only.
- Orally active and selective GCN2 inhibitor.
- Exhibits an IC50 of 5 nM against GCN2.
- Demonstrates anti-tumor activity in vivo.
- Alleviates MDSC-related T cell suppression and restores T cell proliferation in vitro.
- Shows robust target engagement in Balb/c mice.
- Inhibits tumor growth in the LL2 syngeneic mouse model.
- Soluble in DMSO (50 mg/mL).
- Can be prepared in 10% DMSO, 90% Corn Oil for in vivo studies.
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