Medchemexpress LLC GCN2-IN-7 | 2396465-33-9 | C22H23BrN8OS | 5 MG

Supplier:  Medchemexpress LLC HY1514605MG

GCN2-IN-7 (compound 39) is an orally active and selective general control nonderepressible 2 (GCN2) inhibitor with an IC50 of 5 nM. It exhibits anti-tumor activity in vivo. Research demonstrates its ability to alleviate myeloid-derived suppressive cells (MDSC)-related T cell suppression and restore T cell proliferation in CD8+ T cells. In vivo studies show robust target engagement and significant reduction of downstream marker Activation Transcription Factor 4 (ATF4), alongside inhibition of tumor growth.

• Orally active and selective GCN2 inhibitor with an IC50 of 5 nM
• Exhibits anti-tumor activity in vivo
• Alleviates MDSC-related T cell suppression and restores T cell proliferation
• Shows robust target engagement in tumor and spleen
• Reduces downstream marker Activation Transcription Factor 4 (ATF4)
• Inhibits tumor growth in a syngeneic mouse model

Catalog No. 50-003-74137