Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
Apexbio Technology LLC GDC-0152 873652-48-3 10mg
Supplier: Apexbio Technology LLC A422410
GDC-0152 (CAS 873652-48-3) is a small-molecule antagonist of inhibitor of apoptosis proteins (IAPs) including ML-IAP XIAP cIAP1 and cIAP2 It binds to the BIR domain of ML-IAP and the BIR3 domains of XIAP cIAP1 and cIAP2 with reported Ki values of 14 nM 28 nM 17 nM and 43 nM respectively GDC-0152 promotes degradation of cIAP1 and induces caspase-3/7 activation resulting in reduced viability of breast cancer cells while sparing normal epithelial cells In cellular models GDC-0152 disrupts interactions between XIAP and caspase-9 and between IAPs and Smac supporting its utility in apoptosis-related cancer research
This item is not returnable.
View return policy
Product Title
By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.
Spot an opportunity for improvement?