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Medchemexpress LLC GDC-0310 | 1788063-52-4 | 98.8% | 543.48 | 50 MG
Supplier: Medchemexpress LLC HY13908150MG
GDC-0310 is a selective acyl-sulfonamide Nav1.7 inhibitor, demonstrating an IC50 of 0.6 nM for hNav1.7. It exhibits an EC50 of 1.1 μM in vivo and a Ki of 1.8 nM for Nav1.7, showcasing improved Nav selectivity and ADME properties.
- Selective acyl-sulfonamide Nav1.7 inhibitor
- IC50 of 0.6 nM for hNav1.7
- EC50 of 1.1 μM in vivo
- Ki of 1.8 nM for Nav1.7
- Improved Nav selectivity and ADME properties
- Exhibits t1/2 values of 5 h in rat, 46 h in dog, and 4.4 h in cynomolgus monkeys
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