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Medchemexpress LLC GDP366 | 501698-03-9 | 375.45 | 100 MG
Supplier: Medchemexpress LLC HYU00177100MG
GDP366 is a dual inhibitor of survivin and Op18. It induces cell growth inhibition, cellular senescence, and mitotic catastrophe in human cancer cells. This compound potently and selectively inhibits the expression of both survivin and Op18 by decreasing their mRNA and protein levels. It significantly inhibits tumor cell growth in vitro and in vivo without rapidly inducing apoptosis.
- Dual inhibitor of survivin and Op18
- Induces cell growth inhibition
- Induces cellular senescence
- Induces mitotic catastrophe in human cancer cells
- Potently and selectively inhibits survivin and Op18 expression
- Increases p53 and p21 levels
- Inhibits tumor cell growth in vitro and in vivo
- Causes polyploidy in multiple cancer cell lines
- Increases chromosomal instability
- Induces cellular senescence by inhibiting telomerase activity
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