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AdipoGen GE2270 D2

Supplier: AdipoGen AGCN20304M001

Chemical. CAS 138948-60-4. Formula C55H53N15O10S6. MW 1276.5. Isolated from Planobispora rosea. Thiopeptide antibiotic. Congener of GE2270A. Used as a starting scaffold bearing a free hydroxy group, for the production of new interesting semi-synthetic antibiotics. Antibacterial agent by inhibiting bacterial protein synthesis. Active against numerous Gram-positive pathogens. Inhibitor of elongation factor Tu EF-Tu. Inhibits protein synthesis by blocking the GDP to GTP conformational change and by directly competing with aminoacyl-tRNA for the same binding site on EF-Tu.
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