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Medchemexpress LLC Geldanamycin (Standard) | 30562-34-6 | C29H40N2O9 | 25 MG
Supplier: Medchemexpress LLC 25MGHY15230
Geldanamycin is an Hsp90 inhibitor with antimicrobial activity against various Gram-positive and some Gram-negative bacteria, and also demonstrates anti-influenza virus H5N1 activities. This analytical standard protects against neuronal injury and decreases RIP1 protein levels. It is recognized as the first natural product inhibitor of Hsp90, binding to its N-terminal ATPase domain to inhibit chaperone function and induce tumor cell death through an apoptotic mechanism.
- Hsp90 inhibitor
- Antimicrobial activity
- Anti-influenza virus H5N1 activities
- Protects against neuronal injury
- Decreases RIP1 protein levels
- Purity 99.43%
- Molecular weight 560.64
- Light yellow to orange solid
- Initial source: Microorganisms (Streptomyces hygroscopicus)
- Kd for Hsp90: 1.2 μM
- Solubility in DMSO: 25 mg/mL
- Melting/freezing point: 255°C
- Stable under recommended storage conditions
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