Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
Cayman Chemical Gelsevrne 5mg
Supplier: Cayman Chemical 397495 MG
An oxindole alkaloid with anti-inflammatory activity; binds to STING (Kd = 27.6 µM) and prevents 2'3'-cGAMP-induced Sting dimerization in RAW 264.7 cells at 5 µM; inhibits 2'3'-cGAMP-, poly(dA:dT) dsDNA-, or IFN-stimulatory DNA-induced increases in the levels of mRNA encoding CXCL10 and IL-6 in THP-1 monocytes and RAW 264.7 cells at 10 µM; inhibits 2'3'-cGAMP-induced increases in the levels of Sting and phosphorylated IRF3, p65, and TBK1 in RAW 264.7 cells at 5 µM; increases animal survival time, reduces lung injury and total protein levels in BALF, and decreases serum levels of ALT, AST, creatinine, IL-6, TNF-α, and BUN levels in a mouse model of sepsis induced by CLP at 20 mg/kg
Product Title
By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.
Spot an opportunity for improvement?