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Apexbio Technology LLC GGsTop(Synonyms: GGsTop inhibitor, GGT inhibitor, gamma-glutamyl transpeptidase inhibitor), 10mg, CAS: 926281-37-0.
Supplier: Apexbio Technology LLC B560210
GGsTop (CAS 926281-37-0) is a selective irreversible inhibitor targeting the enzyme -glutamyl transpeptidase (GGT) with a reported Ki of 0 17 mM GGT regulates extracellular glutathione (GSH) homeostasis via cleavage of -glutamyl peptide bonds GGsTop inhibits GGT activity in both bacterial (E coli) and human systems In animal studies GGsTop administration led to increased lung lining fluid GSH levels reduced airway mucus accumulation and lowered airway hyperresponsiveness suggesting therapeutic relevance to inflammation-related oxidative lung injury models Additionally GGsTop alleviated renal tissue damage and improved renal function in ischemia/reperfusion-induced acute kidney injury models in rats
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