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Medchemexpress LLC Gisadenafil besylate | 334827-98-4 | 677.79 | 1 ML
Supplier: Medchemexpress LLC HY10861910MG
Gisadenafil besylate (UK 369003-26) is a specific, orally active phosphodiesterase 5 (PDE5) inhibitor with an IC50 of 3.6 nM and prevents degradation of cyclic guanosine monophosphate (cGMP).
- Specific, orally active phosphodiesterase 5 (PDE5) inhibitor.
- IC50 for PDE5A is 3.6 nM.
- Inhibits PDE1A with an IC50 of 9.1 μM, showing an approximately 2500-fold difference in specificity for PDE5A.
- In vivo, Gisadenafil (2 mg/kg; intraperitoneal injection) largely restores the normal increase in cortical flow following hypercapnia in Tat-tg mice (17.5% above baseline).
- Restores the dilation of small (<25 μm) arterioles following hypercapnia.
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