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ABclonal Technology GLI2 Rabbit mAb
Supplier: ABclonal Technology A2309420UL
This gene encodes a protein which belongs to the C2H2-type zinc finger protein subclass of the Gli family Members of this subclass are characterized as transcription factors which bind DNA through zinc finger motifs These motifs contain conserved H-C links Gli family zinc finger proteins are mediators of Sonic hedgehog (Shh) signaling and they are implicated as potent oncogenes in the embryonal carcinoma cell The protein encoded by this gene localizes to the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression It is also thought to play a role during embryogenesis The encoded protein is associated with several phenotypes- Greig cephalopolysyndactyly syndrome Pallister-Hall syndrome preaxial polydactyly type IV postaxial polydactyly types A1 and B
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